Oh, Pfizer.  You just love acquisitions, don’t you?

Pfizer has reportedly bid $4 billion Euros (or roughly $5.4 billion U.S. dollars) for German generic drugmaker, Ratiopharm.  This acquisition would thrust PFE into the big leagues of generic drugs with annual sales of roughly $11 billion compared to the biggest player, Teva Pharmaceuticals (TEVA), which had $13.9 billion in 2009 revenue.

I figured Pfizer would want to focus on integrating the massive Wyeth acquisition, which cost them more than $65 billion, before prowling for additional acquisitions to combat patent losses.  The price tag doesn’t really concern me because Pfizer has plenty of cash and investing in a generics business makes some sense.  In addition, global scale is critical to generics, so buying the top manufacturer in the EU’s largest market (Germany) is wise.

I suppose my main concern is the vastly different economic of generics compared to the Big Pharma model.  Integrating a business with intense cost competition will be more complicated than just writing a big check and eliminating overlapping business costs.

Another concern is that annual generic sales totaled just $83 billion, according to IMS, while PFE alone generates more than $60 billion with much more attractive margins.  Significant patent cliffs mean $150 billion in annual sales will go generic by 2014, but growth will then slow substantially.

I guess Pfizer is shrinking it research spending for a reason: they are going to purchase future revenues for the foreseeable future.  Ok, so PFE is officially no longer a growth stock.  That’s no big deal if they keep paying a fat dividend (current yield of 4.17%) and find ways to grow the dividend at a meaningful rate.

While on the topic of PFE, I should acknowledge that earlier this week an experimental Alzheimer’s treatment, Dimebon, failed to show effectiveness in a large late-stage study.  This is one of the drugs I mentioned in this post as a catalyst for 2010 performance.  In short, the results were very disappointing to investors.